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Introduction to Pharmacology, Second Edition
Introduction to Pharmacology
© 1997, 2003 Taylor & Francis
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In the ocean depths off Madagascar, obsolete fish keep their laggard appointments.
In the depths of the human mind, obsolete assumptions go their daily rounds. And
there is little difference between the two, except that the fish do no harm.
Robert Ardrey
African Genesis , 1967
That which in the beginning may be just like poison, but at the end is like nectar,
and which awakens one to self-realization, is said to be happiness in the mode of
goodness.
Bhagavad Gita
Nothing in life is to be feared, it is only to be understood.
Marie Curie
© 1997, 2003 Taylor & Francis
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Introduction to Pharmacology
Second Edition
Mannfred A. Hollinger, Ph.D.
Professor Emeritus,
Department of Medical
Pharmacology and Toxicology
University of California, Davis
© 1997, 2003 Taylor & Francis
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First published 1997 by Taylor & Francis
Second edition published 2003 by Taylor & Francis
11 New Fetter Lane, London EC4P 4EE
Simultaneously published in the USA and Canada
by Taylor & Francis Inc,
29 West 35th Street, New York, NY 10001
Taylor & Francis is an imprint of the Taylor & Francis Group
© 1997, 2003 Taylor & Francis
Typeset in 10/12 pt Sabon by Graphicraft Limited, Hong Kong
Printed and bound in Great Britain by TJ International Ltd, Padstow, Cornwall
All rights reserved. No part of this book may be reprinted or reproduced or
utilised in any form or by any electronic, mechanical, or other means, now
known or hereafter invented, including photocopying and recording, or in any
information storage or retrieval system, without permission in writing from
the publishers.
Every effort has been made to ensure that the advice and information in this
book is true and accurate at the time of going to press. However, neither the
publisher nor the authors can accept any legal responsibility or liability for any
errors or omissions that may be made. In the case of drug administration, any
medical procedure or the use of technical equipment mentioned within this
book, you are strongly advised to consult the manufacturer’s guidelines.
British Library Cataloguing in Publication Data
A catalogue record for this book is available from the British Library
Library of Congress Cataloging in Publication Data
Hollinger, Mannfred A.
Introduction to pharmacology / Mannfred A. Hollinger.—2nd ed.
p. cm.
Includes bibliographical references and index.
1. Pharmacology. I. Title.
[DNLM: 1. Pharmacology. 2. Pharmaceutical Preparations. QV 4 H74li
2003]
RM300 .H65 2003
615 ′ .1—dc21
2002072005
ISBN 0-415-28033-8 (hbk)
ISBN 0-415-28034-6 (pbk)
© 1997, 2003 Taylor & Francis
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Contents
Acknowledgements
vii
Preface to the first edition
viii
Preface to the second edition
x
PART 1
Fundamentals of pharmacokinetics
1
1 Introduction
3
2 Absorption and distribution
23
3 Metabolism and elimination
44
4 Drug interactions
61
PART 2
Fundamentals of pharmacodynamics and
toxicodynamics
73
5 Drug receptors
75
6 Dose–response relationship
90
7 Drug toxicity
101
8 Treating drug overdose
137
PART 3
Drugs that replace, cure, or treat symptoms
147
9Hormones
149
10 Chemotherapeutic agents
164
11 Drug treatment of symptoms: neuropharmacology and
substance abuse
181
12 Cardiovascular drugs
241
© 1997, 2003 Taylor & Francis
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