Organic Chemistry of Drug Synthesis Volume 2 - DANIEL LEDNICER.pdf

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The Organic Chemistry of Drug Systhesis Vol 2
The Organic Chemistry
of Drug Synthesis
VOLUME 2
DANIEL LEDNICER
Mead Johnson and Company
Evansville, Indiana
LESTER A. MITSCHER
The University of Kansas School of Pharmacy
Department of Medicinal Chemistry
Lawrence, Kansas
A WILEY-INTERSCIENCE PUBLICATION
JOHN WILEY AND SONS, New York • Chichester • Brisbane • Toronto
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Copyright © 1980 by John Wiley & Sons, Inc.
All rights reserved. Published simultaneously in Canada.
Reproduction or translation of any part of this work
beyond that permitted by Sections 107 or 108 of the
1976 United States Copyright Act without the permission
of the copyright owner is unlawful. Requests for
permission or further information should be addressed to
the Permissions Department, John Wiley & Sons, Inc.
Library of Congress Cataloging in Publication Data:
Lednicer, Daniel, 1929-
The organic chemistry of drug synthesis.
"A Wiley-lnterscience publication."
1. Chemistry, Medical and pharmaceutical.
2. Drugs. 3. Chemistry, Organic. I. Mitscher,
Lester A., joint author. II. Title.
RS421 .L423
615M 91
76-28387
ISBN 0-471-04392-3
Printed in the United States of America
10 987654321
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It is our pleasure again to dedicate
a book to our helpmeets: Beryle and Betty.
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"Has it ever occurred to you that medicinal chemists
are just like compulsive gamblers: the next compound
will be the real winner."
R. L. Clark at the 16th National
Medicinal Chemistry Symposium,
June, 1978.
vii
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