The Genetics and Biology of Sex Determination - Novartis Foundation.pdf - medyczne (angielski) - wojtek3101993

The Genetics and Biology of Sex Determination: Novartis Foundation Symposium 244. Volume 244

Edited by Derek Chadwick and Jamie Goode

THE GENETICS AND

BIOLOGY OF SEX

DETERMINATION

Novartis Foundation 2002.

ISBN: 0-470-84346-2

The Novartis Foundation is an international scienti¢c and educational

charity (UK Registered Charity No. 313574). Known until September 1997

as the Ciba Foundation, it was established in 1947 by the CIBA company

of Basle, which merged with Sandoz in 1996, to form Novartis. The

Foundation operates independently in London under English trust

law. It was formally opened on 22 June 1949.

The Foundation promotes the study and general knowledge of

science and in particular encourages international co-operation in

scienti¢c research. To this end, it organizes internationally

acclaimed meetings (typically eight symposia and allied open

meetings and 15^20 discussion meetings each year) and publishes

eight books per year featuring the presented papers and discussions

from the symposia. Although primarily an operational rather than

a grant-making foundation, it awards bursaries to young scientists

to attend the symposia and afterwards work with one of the other

participants.

The Foundation’s headquarters at 41 Portland Place, London W1B 1BN,

provide library facilities, open to graduates in science and allied disciplines.

Media relations are fostered by regular press conferences and by articles

prepared by the Foundation’s Science Writer in Residence. The Foundation

o¡ers accommodation and meeting facilities to visiting scientists and their

societies.

Information on all Foundation activities can be found at

http://www.novartisfound.org.uk

Novartis Foundation Symposium 244

THE GENETICS AND

DETERMINATION

2002

JOHN WILEY & SONS, LTD

BIOLOGY OF SEX

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Novartis Foundation Symposium 244

ix+266 pages, 40 ¢gures, 13 tables

Library of Congress Cataloging-in-Publication Data

The genetics and biology of sex determination / [editors, Derek Chadwick, Jamie Goode].

p. cm. ^ (Novartis Foundation symposium ; 244)

Includes bibliographical references and indexes.

ISBN0-470-84346-2 (alk. paper)

1. Sex determination, Genetic ^Congresses. I. Chadwick, Derek. II. Goode, Jamie. III.

Series.

QP278.5 .G466 2002

571.8 ’ 1^dc21

2001057371

British Library Cataloguing in PublicationData

A catalogue record for this book is available from the British Library

ISBN 0 470 84346 2

Ty p e s e t i n 1 0 1 2 on 12 1 2 pt Garamond by DobbieTypesetting Limited,Tavistock, Devon.

Printed and bound in Great Britain by Biddles Ltd, Guildford and King’s Lynn.

This book is printed on acid-free paper responsibly manufactured from sustainable forestry,

in which at least two trees are planted for each one used for paper production.

Contents

Symposium onThe genetics and biology ofsexdetermination, held atthe Novartis Foundation,

London,1^3May 2001

Editors: Derek Chadwick (Organizer) and Jamie Goode

This symposium is based on a proposal made by Peter Koopman

RogerV. Short Chair’s introduction 1

Robin Lovell-Badge, Clare Canning and Ryohei Sekido Sex-determining genes

in mice: building pathways 4

Discussion 18

Jian-Kan Guo, Annette Hammes, Marie-Christine Chaboissier,ValerieVidal,

YimingXing, FrancesWong andAndreas Schedl Earlygonadal development:

exploringWt1 and Sox9 function 23

Discussion 31

General discussion I The mechanism of action of SRY 35

EricVilain Anomalies of human sexual development: clinical aspects and genetic

analysis 43

Discussion 53

Vincent R. Harley The molecular action of testis-determining factors SRYand

SOX9 57

Discussion 66

Taiga Suzuki, Hirofumi Mizusaki, Ken Kawabe, Megumi Kasahara,

Hidefumi Yoshioka and Ken-ichirou Morohashi Concerted regulation of

gonad di¡erentiation by transcription factors and growth factors 68

Discussion 77

General discussion II 79

Jennifer A. Marshall Graves Evolution of the testis-determining genethe rise

and fall of SRY 86

Discussion 97

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