Pharmacology - Dipiro - Pharmacotherapy, A Pathophysiologic Approach - Joseph T Dipiro, Et Al (6Th Ed , Mcgraw-Hill, 2005).pdf

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Pharmacotherapy
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Sixth Edition
PHARMACOTHERAPY
A Pathophysiologic Approach
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Notice
Medicine is an ever-changing science. As new research and clinical experience broaden our
knowledge, changes in treatment and drug therapy are required. The editors and the publisher
of this work have checked with sources believed to be reliable in their efforts to provide
information that is complete and generally in accord with the standards accepted at the time of
publication. However, in view of the possibility of human error or changes in medical sciences,
neither the editors nor the publisher nor any other partywho has been involved in the preparation
or publication of this work warrants that the information contained herein is in every respect
accurate or complete, and they disclaim all responsibility for any errors or omissions or for the
results obtained from use of the information contained in this work. Readers are encouraged
to confirm the information contained herein with other sources. For example and in particular,
readers are advised to check the product information sheet included in the package of each
drug they plan to administer to be certain that the information contained in this work is accurate
and that changes have not been made in the recommended dose or in the contraindications for
administration. This recommendation is of particular importance in connection with new or
infrequently used drugs.
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Sixth Edition
PHARMACOTHERAPY
A Pathophysiologic Approach
Editors
Joseph T. DiPiro, PharmD, FCCP
Professor and Executive Dean, South Carolina College of Pharmacy,
University of South Carolina, Columbia, and Medical University of South Carolina, Charleston
Robert L. Talbert, PharmD, FCCP, BCPS
Professor, College of Pharmacy, University of Texas at Austin;
Professor, Departments of Medicine and Pharmacology, University of Texas Health Science Center at San Antonio, Texas
Gary C. Yee, PharmD, FCCP
Professor and Chair, Department of Pharmacy Practice, College of Pharmacy,
University of Nebraska Medical Center, Omaha, Nebraska
Gary R. Matzke, PharmD, FCP, FCCP
Professor, Department of Pharmacy and Therapeutics, School of Pharmacy,
Renal-Electrolyte Division, School of Medicine,
University of Pittsburgh, Pittsburgh, Pennsylvania
Barbara G. Wells, PharmD, FASHP, FCCP, BCPP
Dean and Professor, School of Pharmacy, The University of Mississippi, University, Mississippi
L. Michael Posey, BS Pharm
President, PENS Pharmacy Editorial and News Services, Athens, Georgia
M C GRAW-HILL
Medical Publishing Division
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Pharmacotherapy: A Pathophysiologic Approach, Sixth Edition
2005, 2002 by The McGraw-Hill Companies, Inc. All rights
reserved. Printed in the United States of America. Except as permitted under
the United States Copyright Act of 1976, no part of this publication may be
reproduced or distributed in any form or by any means, or stored in a database
or retrieval system, without the prior written permission of the publisher.
Previous editions copyright C
1999, 1997, 1993 by Appleton & Lange.
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This book was set in Times Roman by TechBooks, Inc.
The editors were Michael Brown, Andrew Hall, Karen G. Edmonson, and
Peter J. Boyle.
The production supervisor was Richard Ruzycka.
The text designer was Joan O’Connor.
The cover designer was Elizabeth Pisacreta.
Barbara Littlewood prepared the index.
RR Donnelley was printer and binder.
This book is printed on acid-free paper.
1999 by Obi-Tabot Tabe. The images used on the
cover and spine are taken from a 9 × 4-1/2 oil painting by Obi-Tabot Tabe,
PharmD, a painter, graphic designer, scientific illustrator, and pharmacist.
Dr. Tabe, originally from Cameroon, is a graduate of the University of
Pittsburgh, School of Pharmacy. The painting incorporates the artist’s
impressions of concepts introduced in the pharmacy curriculum. The painting
can be seen in the student lounge of Salk Hall at the university.
Cataloging-in-publication data is on file for this title at the Library of Congress.
Copyright C
Cover images copyright C
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