Challenges in Inflammatory Bowel Disease, 2nd edition.pdf

CHALLENGES IN

Inﬂammatory Bowel Disease

CHALLENGES IN

..................................................................................................................................................................................................................

Inﬂammatory Bowel Disease

EDITED BY

Derek P. Jewell

Neil J. Mortensen

A. Hillary Steinhart

John H. Pemberton

Bryan F. Warren

Second edition

2001, 2006 by Blackwell Publishing Ltd

Blackwell Publishing, Inc., 350 Main Street, Malden, Massachusetts 02148-5020, USA

Blackwell Publishing Ltd, 9600 Garsington Road, Oxford OX42DQ, UK

Blackwell Publishing Asia Pty Ltd, 550 Swanston Street, Carlton, Victoria 3053, Australia

The right of the Authors to be identiﬁed as the Authors of this Work has been asserted in accordance

with the Copyright, Designs and Patents Act 1988.

transmitted, in any form or by any means, electronic, mechanical, photocopying, recording or

otherwise, except as permitted by the UK Copyright, Designs and Patents Act 1988, without the prior

permission of the publisher.

First published 2001

Second edition 2006

1 2006

Catalogue records for this title are available from the British Library and Library of Congress

ISBN-13: 978-1-4051-2234-4

ISBN-10: 1-4051-2234-X

Set in 9.25/12 by TechBooks, India

Printed and bound in India by Replika Press Pvt., Ltd

Commissioning Editor: Alison Brown

Editorial Assistant: Saskia van der Linden

Development Editor: Fiona Pattison

Production Controller: Kate Charman

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http://www.blackwellpublishing.com

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and which has been manufactured from pulp processed using acid-free and elementary chlorine-free

practices. Furthermore, the publisher ensures that the text paper and cover board used have met

acceptable environmental accreditation standards.

Contents

List of Contributors and Editors vii

Preface xi

III Management of ulcerative colitis 117

9 MILES P. SPARROW, WEE-CHIAN LIM AND

STEPHEN B. HANAUER: Mesalazine for

maintenance therapy in ulcerative colitis –

how much, how long? 119

I Clues to aetiology and pathogenesis 1

1 RICHARD F. A. LOGAN AND EMMA L.

ARMITAGE: Global changes in incidence 3

10 SIMON TRAVIS: Refractory distal

colitis 124

2 JOHN B. BECKLY, TARIQ AHMAD AND

DEREK P. JEWELL:The role of genetics in

inﬂammatory bowel disease 14

11 FERGUS SHANAHAN, JUDE RYAN AND

SHOMIK SIBARTIE: Pharmabiotics and

inﬂammatory bowel disease – on the verge

of evidence-based medicine 144

3 ROBIN G. LORENZ AND CHARLES O.

ELSON: Microbial sensing in the intestine

by pattern recognition receptors 33

12 R. JOHN NICHOLLS AND MARK J.

CHEETHAM: Current controversies in the

surgical management of ulcerative

colitis 154

4 ROBERT PENNER AND KAREN MADSEN:

The role of bacteria 44

5 KENNETH CROITORU: The appendix – how

might it inﬂuence susceptibility to ulcerative

colitis: the legend of Qebehsenuef 57

13 ALAN F. HORGAN, WILLIAM J. SANDBORN

AND JOHN H. PEMBERTON: What are the

causes and treatment of ileoanal pouch

dysfunction? 167

II Diagnosis and assessment 65

6 BRYAN F. WARREN AND NEIL A.

SHEPHERD: What are the controversies in

histopathological diagnosis? 67

IV Management of Crohn’s disease 179

14 A. HILLARY STEINHART: Is mesalazine

useful in Crohn’s disease? 181

7 GARY C. CHEN AND SIMON K. LO: The

challenges of using capsule endoscopy in the

diagnosis and management of inﬂammatory

bowel disease 85

15 MIQUEL A. GASSULL: Steroids or

nutrition? 194

8 STUART TAYLOR AND STEVE HALLIGAN:

Cross-sectional imaging of inﬂammatory

bowel disease 105

16 S EVERINE VERMEIRE AND PAUL

RUTGEERTS: Do antibiotics have a role in

Crohn’s disease? 206

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