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MM09_ATP.AI
AEROBIC OXIDATION OF GLUCOSE
ATP YIELD
GLUCOSE
ATP
Glucose-6- P
Fructose-6- P
ADP
ATP
Fructose-1,6-bis- P
ADP
Glycerone-3- P
(Di-OH-acetone- P)
2
3-P-Glyceraldehyde
2 NAD
2P i
2NADH+2H +
2
1,3-bis-P-Glycerate
2ADP
2
3-P-Glycerate
2-P-Glycerate
2ATP
2
2
P-enol pyruvate
2H O
2
2ADP
Net gain in
Glycolysis
2ATP
2ATP
2 PYRUVATE
MITOCHIONDRIAL INNER MEMBRANE
2 PYRUVATE
1.6.5.3
2
ACETYL-CoA
FMN H 2
I
FMN
Fe-S
1.6.5.3
2 Oxaloacetate
4 0
4
4
2
Citrate
2
Shuttle
2
Malate
2NADH+2H +
10NADH+10H +
UQ
FAD H 2
Fe-S
1.3.5.1
2
Isocitrate
Cyt.b
Ubiquino n e
Cycle
- OO CCH=CHCOO -
2
2
II
2
Fumarate
FAD
1.3.5.1
2
2-Oxoglutarate
40
8
4
4
UQH 2
H H
2
- OOCCH-CHCOO -
2
Cyt.b
2H +
2
Succinate
Succinyl-CoA
P i
2
Fe-S
MITOCHONDRIAL
MATRIX
Cyt.c 1
III
2
GDP
2
GTP
ATP
Cyt.c
2
ATP
3.6.1.34
F 1
Cu A
1 / 2 O 2
2
ADP
Cyt.a
Cy t .a 3
Cu B
2
P i
P
P i
ATP
IV
2 H +
P i
20
4
2
2
HO
2
2
1
ADP
ADP
ADP
3
2
112
F 0
2
2ADP
ADP
INTER -MEMBRANE SPACE
P i
P i
2ATP
2
INTERMEMBRANE SPACE
1ATP
ONS
1
3
E
T
APPROXIMATE ATP YIELD PER MOLE OF GLUCOSE
4 Translocated Protons
1ATP
ONS
112 Translocated Protons
from (10NAD H +10 H + ) + 2 Succinate
28 ATP
CYTOPLASM
Add 2 GTP from TCA Cycle in Matrix
less 0.5 ATP for translocation of 2P i
for phosphorylation of 2GDP
1.5 ATP
Less 0.5 ATP for translocation of 4H +
in Malate-Aspartate Shuttle
-0.5 ATP
Add 2 ATP from Glycolysis
2 ATP
31 ATP
CYTOPLASMIC MEMBRANE
COMPLEX I
COMPLEX II
COMPLEX III
COMPLEX IV
ATP-synthase
3.6.1.34
NADH dehydrogenase
(ubiquinone)
Succinate
dehydrogenase
(ubiquinone)
1.3.5.1
cytochrome-c
Ubiquinol-
Cytochrome-c
oxidase
reductase
1.6.5.3
1.9.3.1
AEROBIC OXIDATION OF GLUCOSE - using Malate-Aspartate Shuttle
C 6 H 12 O 6+ 6O 2 + ~ (31 ADP + 31 P i )
6CO 2 +6H 2 O + ~ (31 ATP + 31 H 2 O)
The human need for ATP is so great that it is calculated that we synthesise our body’s weight each day
c 2001 IUBMB
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