Cardiac Drug Therapy 7th ed.pdf

Cardiac

Therapy

S EVENTH E DITION

M. Gabriel Khan

MD , FRCP ( LONDON ) , FRCP ( C ) , FACP , FACC

Cardiac

Drug

Therapy

S EVENTH E DITION

M. Gabriel Khan

MD , FRCP ( LONDON ) , FRCP ( C ) , FACP , FACC

C ARDIAC D RUG T HERAPY

C ONTEMPORARY C ARDIOLOGY

C HRISTOPHER P. C ANNON , MD

S ERIES E DITOR

A NNEMARIE M. A RMANI , MD

E XECUTIVE E DITOR

Nuclear Cardiology: The Basics: How to Set Up

and Maintain a Laboratory, Second Edition,

by Frans Wackers, MD , P h D , Barry L. Zaret,

MD , P h D , and Wendy Bruni, CNMT , 2008

Rapid ECG Interpretation, Third Edition, by M.

Gabriel Khan, MD , FRCP , 2007

Therapeutic Lipidology, edited by Michael H. David-

son, MD , Kevin C. Maki, P h D , and Peter P. Toth,

MD , P h D , 2007

Essentials of Restenosis: For the Interventional

Cardiologist, edited by Henricus J. Duckers,

P h D , MD , Patrick W. Serruys, MD , and Elizabeth

G. Nabel, MD , 2007

Cardiac Drug Therapy, Seventh Edition, by M. Gabriel

Khan, MD , FRCP ( LONDON ) , FRCP ( C ), FACP , FACC , 2007

Cardiovascular Magnetic Resonance Imaging ,

edited by Raymond Y. Kwong, MD , 2007

Essential Echocardiography: A Practical Handbook

With DVD, edited by Scott D. Solomon, MD ,

2007

Management of Acute Pulmonary Embolism ,

edited by Stavros Konstantinides, MD , 2007

Stem Cells and Myocardial Regeneration , edited

by Marc S. Penn, MD , P h D , 2007

Handbook of Complex Percutaneous Carotid

Intervention , edited by Jacqueline Saw, MD ,

Jose Exaire, MD , David S. Lee, MD , Sanjay

Yadav, MD , 2007

Preventive Cardiology: Insights Into the Prevention

and Treatment of Cardiovascular Disease,

Second Edition, edited by JoAnne Micale

Foody, MD , 2006

The Art and Science of Cardiac Physical

Examination: With Heart Sounds and Pulse

Wave Forms on CD, by Narasimhan

Ranganathan, MD , Vahe Sivaciyan, MD ,

and Franklin B. Saksena, MD , 2006

Cardiovascular Biomarkers: Pathophysiology

and Disease Management, edited by David A.

Morrow, MD , 2006

Cardiovascular Disease in the Elderly , edited by

Gary Gerstenblith, MD , 2005

Platelet Function: Assessment, Diagnosis, and

Treatment, edited by Martin Quinn, MB BC h

BAO , P h D , and Desmond Fitzgerald, MD , FRCPI ,

FESC , APP , 2005

Diabetes and Cardiovascular Disease, Second

Edition, edited by Michael T. Johnstone, MD , CM ,

FRCP ( C ), and Aristidis Veves, MD , DS c , 2005

Angiogenesis and Direct Myocardial Revascular-

ization, edited by Roger J. Laham, MD , and

Donald S. Baim, MD , 2005

Interventional Cardiology: Percutaneous

Noncoronary Intervention, edited by

Howard C. Herrmann, MD , 2005

Principles of Molecular Cardiology , edited by Marschall

S. Runge, MD , and Cam Patterson, MD , 2005

Heart Disease Diagnosis and Therapy: A Practical

Approach, Second Edition, by M. Gabriel Khan,

MD , FRCP (L ONDON ), FRCP ( C ), FACP , FACC , 2005

Cardiovascular Genomics: Gene Mining for

Pharmacogenomics and Gene Therapy,

edited by Mohan K. Raizada, P h D , Julian F.

R. Paton, P h D , Michael J. Katovich, P h D , and

Sergey Kasparov, MD , P h D , 2005

Surgical Management of Congestive Heart Failure ,

edited by James C. Fang, MD

and Gregory S. Couper, MD , 2005

Cardiopulmonary Resuscitation , edited by Joseph P.

Ornato, MD , FACP , FACC , FACEP and Mary Ann

Peberdy, MD , FACC , 2005

CT of the Heart: Principles and Applications, edited

by U. Joseph Schoepf, MD , 2005

Coronary Disease in Women: Evidence-Based Diag-

nosis and Treatment, edited by Leslee J. Shaw,

P h D and Rita F. Redberg, MD , FACC , 2004

Cardiac Transplantation: The Columbia University

Medical Center/New York-Presbyterian

Hospital Manual, edited by Niloo M. Edwards,

MD , Jonathan M. Chen, MD , and Pamela A.

Mazzeo, 2004

Heart Disease and Erectile Dysfunction , edited by

Robert A. Kloner, MD , P h D , 2004

Complementary and Alternative Cardiovascular

Medicine, edited by Richard A. Stein, MD

and Mehmet C. Oz, MD , 2004

Nuclear Cardiology, The Basics: How to Set Up

and Maintain a Laboratory, by Frans J. Th.

Wackers, MD , P h D , Wendy Bruni, BS , CNMT ,

and Barry L. Zaret, MD , 2004

C ARDIAC D RUG T HERAPY

Seventh Edition

M. G ABRIEL K HAN , MD , FRCP , FACC

Associate Professor of Medicine, University of Ottawa, and

Cardiologist, The Ottawa Hospital,

Ottawa, Ontario, Canada

999 Riverview Drive, Suite 208

Totowa, New Jersey 07512

www.humanapress.com

by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise without written permission

from the Publisher.

The content and opinions expressed in this book are the sole work of the authors and editors, who have warranted due

diligence in the creation and issuance of their work. The publisher, editors, and authors are not responsible for errors

or omissions or for any consequences arising from the information or opinions presented in this book and make no

warranty, express or implied, with respect to its contents.

Due diligence has been taken by the publishers, editors, and authors of this book to assure the accuracy of the information

published and to describe generally accepted practices. The contributors herein have carefully checked to ensure that

the drug selections and dosages set forth in this text are accurate and in accord with the standards accepted at the time

of publication. Notwithstanding, as new research, changes in government regulations, and knowledge from clinical

experience relating to drug therapy and drug reactions constantly occurs, the reader is advised to check the product

information provided by the manufacturer of each drug for any change in dosages or for additional warnings and

contraindications. This is of utmost importance when the recommended drug herein is a new or infrequently used drug.

It is the responsibility of the treating physician to determine dosages and treatment strategies for individual patients.

Further it is the responsibility of the health care provider to ascertain the Food and Drug Administration status of each

drug or device used in their clinical practice. The publisher, editors, and authors are not responsible for errors or

omissions or for any consequences from the application of the information presented in this book and make no warranty,

express or implied, with respect to the contents in this publication.

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Printed in the United States of America. 10 9 8 7 6 5 4 3 2 1

eISBN 1-59745-238-6 ISBN13 978-1-58829-904-8

Library of Congress Cataloging-in-Publication Data

Khan, M. I. Gabriel.

Cardiac drug therapy / by M. Gabriel Khan. — 7th ed.

p. ; cm. — (Contemporary cardiology)

Includes bibliographical references and index.

ISBN-13: 978-1-58829-904-8 (alk. paper)

ISBN-10: 1-58829-904-X (alk. paper)

1. Cardiovascular agents. 2. Heart—Diseases—Chemotherapy. I. Title. II. Series: Contemporary

cardiology (Totowa, N.J. : Unnumbered)

[DNLM: 1. Heart Diseases—drug therapy—Handbooks. 2. Cardiovascular Agents—therapeutic use—

Handbooks. WG 39 K45c 2007]

RC684.C48K437 2007

616.1’2061—dc22 2006032373

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