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Quantum Medicinal Chemistry
Edited by
Paolo Carloni and Frank Alber
Quantum Medicinal Chemistry. Edited by P. Carloni, F. Alber
Copyright © 2003 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
ISBN: 3-527-30456-8
Methods and Principles in Medicinal Chemistry
Edited by
R. Mannhold, H. Kubinyi, G. Folkers
Editorial Board
H.-D. Höltje, H. Timmerman,
J. Vacca, H. van de Waterbeemd, T. Wieland
Quantum Medicinal Chemistry
Edited by
Paolo Carloni and Frank Alber
263049395.002.png
Series Editors
Prof. Dr. Raimund Mannhold
Biomedical Research Center
Molecular Drug Research Group
Heinrich-Heine-Universität
Universitätsstraße 1
40225 Düsseldorf
Germany
raimund.mannhold@uni-duesseldorf.de
This book was carefully produced. Neverthe-
less, editors, authors and publisher do not
warrant the information contained therein to
be free of errors. Readers are advised to keep
in mind that statements, data, illustrations,
procedural details or other items may inad-
vertently be inaccurate.
Cover illustration
Electron density map of morphine showing
the aromatic and part of the furanoid ring.
Courtesy of C. Matta.
Library of Congress Card No.: applied for
British Library Cataloguing-in-Publication Data
A catalogue record for this book is available
from the British Library.
Bibliographic information published by
Die Deutsche Bibliothek
Die Deutsche Bibliothek lists this publication
in the Deutsche Nationalbibliografie; detailed
bibliographic data is available in the Internet
at http://dnb.ddb.de.
ISBN 3-527-30456-8
© 2003 WILEY-VCH Verlag GmbH & Co.
KGaA, Weinheim
Printed on acid free paper
All rights reserved (including those of trans-
lation in other languages). No part of this
book may be reproduced in any form – by
photoprinting, microfilm, or any other
means – nor transmitted or translated into
machine language without written permissi-
on from the publishers. Registered names,
trademarks, etc. used in this book, even
when not specifically marked as such, are
not to be considered unprotected by law.
Prof. Dr. Hugo Kubinyi
BASF AG Ludwigshafen
c/o Donnersbergstraße 9
67256 Weisenheim am Sand
Germany
kubinyi@t-online.de
Prof. Dr. Gerd Folkers
Department of Applied Biosciences
ETH Zürich
Winterthurer Straße 190
8057 Zürich
Switzerland
folkers@pharma.ethz.ch
Volume Editors
Prof. Dr. Paolo Carloni
International School for Advanced Studies
Via Beirut 4
34014 Trieste
Italy
carloni@sissa.it
Dr. Frank Alber
Laboratories of Molecular Biophysics
The Rockefeller University
1230 York Avenue, Box 270
New York, NY 10021-6399
USA
current address:
Dept. of Biopharmaceutical Sciences
University of California
San Francisco, CA 94143
USA
frank.alber@salilab.org
Composition K+V Fotosatz GmbH,
64743 Beerfelden
Printing Strauss Offsetdruck GmbH,
Mörlenbach
Bookbinding J. Schäffer GmbH&Co. KG.,
Grünstadt
Printed in the Federal Republic of Germany
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