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JAVA FOR BIOINFORMATICS AND
BIOMEDICAL APPLICATIONS
JAVA FOR BIOINFORMATICS AND
BIOMEDICAL APPLICATIONS
by
Harshawardhan Bal
Booz Allen Hamilton, Inc., Rockville, MD
and
Johnny Hujol
Vertex Pharmaceuticals, Inc., Cambridge, MA
^
Spri
ringer
Library of Congress Control Number: 2006930294
ISBN-10: 0-387-37235-0
e-ISBN-10: 0-387-37237-7
ISBN-13: 978-0-387-37237-8
Printed on acid-free paper.
© 2007 Springer Science-HBusiness Media, LLC
All rights reserved. This work may not be translated or copied in whole or in part without the
written permission of the publisher (Springer Science-t-Business Media, LLC, 233 Spring Street,
New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly
analysis. Use in connection with any form of information storage and retrieval, electronic
adaptation, computer software, or by similar or dissimilar methodology now known or hereafter
developed is forbidden.
The use in this publication of trade names, trademarks, service marks and similar terms, even if
they are not identified as such, is not to be taken as an expression of opinion as to whether or not
they are subject to proprietary rights.
Printed in the United States of America.
987654321
springer.com
Contents
Foreword
IX
Background and history
IX
Interfaces and standards
X
Java as a platform
X
The future
XI
Preface
XIII
Chapter 1
1
Introduction to Bioinformatics and Java 1
The Origins of Bioinformatics 1
Current State of Biomedical Research 3
The cancer Biomedical Informatics Grid program 6
caBIG™ Organization and Architecture 7
The Model-View-Controller Framework 9
Web Services and Service-Oriented Architecture 10
CaGrid 11
Let's look at each of the tools in turn and understand how they sub-
serve or address a small component of the bigger research problem. 14
CaArray 14
CaWorkbench 16
RProteomics 17
cPath 17
CaTissue Core, caTissue Clinical Annotation Engine and caTIES...18
CaTissue Core
18
Questions and Exercises
21
Additional Resources
21
Selected Reading
23
Chapter II
25
Introduction
IX
Summary
20
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